International Journal of Pharmacy and Chemistry

Special Issue

The Role of JAK(Janus kinase inhibitor) Inhibitors in Rheumatology

  • Submission Deadline: Apr. 30, 2022
  • Status: Submission Closed
  • Lead Guest Editor: Mohammed Hadi Munshed ALOsami
About This Special Issue
Biologic treatment has changed the strategy of some rheumatologic disorders which were so difficult to control, one of the important drugs in this field is Janus kinase inhibitors which now involved in many types of rheumatologic diseases like rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. They can be used with methotrexate or as monotherapy.
Janus Kinases family is a small group of receptor-associated signaling molecules that is essential to the signal cascade originating from type I and type II cytokine receptors. Inhibition of tyrosine kinases enzymatic activity using small molecules has recently become a powerful tool for treatment of several malignancies. Twenty years after the discovery of these enzymes, two inhibitors for this class of kinases have been approved for clinical use and others are currently in the final stage of development.
This special issue aims to evaluate different types of JAK(Janus kinase inhibitor) Inhibitors efficacy and safety in patients with rheumatoid arthritis as monotherapy and in combination with methotrexare.

The research subjects that this issue will focus on:

  1. (1)Types of JAK(Janus kinase inhibitor) Inhibitors
  2. (2)Their targets and mechanism of action
  3. (3)Efficacy and safety of each type
  4. (4)The effectiveness of monotherapy with JAK(Janus kinase inhibitor) Inhibitors
  5. (5)The comparism of monotherapy with combined JAK(Janus kinase inhibitor) Inhibitors and methotrexate therapy
  6. Keywords:

    1. JAK inhibitors
    2. Rheumatoid Arthritis
    3. Disease modifying antirheumatic drugs
    4. Synthetic DMARDS
    5. Oral Janus kinase inhibitor
    6. Monotherapy
    7. Combination therapy
Lead Guest Editor
  • Mohammed Hadi Munshed ALOsami

    Department of Medicine, University of Baghdad, Baghdad, Iraq