The novel coronavirus disease (COVID-19) is a serious threat to the health of the whole world. Natural products or components play an important role in the prevention and treatment of COVID-19. This special issue receives all studies on novel coronavirus pneumonia preventing and treating related compounds or components with antiviral, anti-inflammatory and antibacterial activities. It covers but not limited to: chemical analysis of antiviral natural compounds; isolation and structural identification of bioactive compounds; action mechanism of natural compounds; and structural modification of natural compounds and total synthesis.